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T9808 |
Tetradecylthioacetic acid
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PPAR
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Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including acti... |
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T10035 |
10,12-Tricosadiynoic acid
|
TDA,TCDA |
Acyltransferase
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10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me... |
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T4535 |
Etomoxir sodium salt
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(R)-Etomoxir sodium salt,Na salt,Etomoxir |
Apoptosis
,
Others
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Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that blocks fatty acid synthesis. Etomoxir sodium salt has antitumor activity. |
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T1889 |
CP-640186
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CP 640186 |
Acetyl-CoA Carboxylase
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CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. |
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T3622 |
CP-640186 hydrochloride
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CP 640186 HCl |
Acetyl-CoA Carboxylase
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CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit... |
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T9768L |
Ninerafaxstat trihydrochloride
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Ninerafaxstat trihydrochloride(2254741-41-6 Free base) |
Others
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Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereb... |
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T19663 |
Triheptanoin
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UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011 |
Others
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Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1. |
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T12356 |
Palmitoylcarnitine
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Palmitoyl DL-carnitine |
Endogenous Metabolite
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Palmitoylcarnitine (Palmitoyl DL-carnitine) is a mitochondrial fatty acid oxidation intermediate that acts as a surfactant. |
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T21468 |
CVT-2738
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UNII-NYS3I6283H,CVT 2738,EC 610-916-8,CVT2738,RS-94287 |
Others
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CVT-2738 (RS-94287) is a metabolite of Ranolazine. Ranolazine is a partial fatty acid oxidation (pFOX) inhibitor and anti-anginal drug. |
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T13810 |
Palmitoylcarnitine chloride
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Palmitoyl DL-carnitine chloride |
PKC
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Palmitoylcarnitine chloride (Palmitoyl DL-carnitine chloride) is a mitochondrial fatty acid oxidation intermediate that mediates intralipid cardioprotection.Palmitoylcarnitine chloride eliminates colorectal cancer cell s... |
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T4535L |
Etomoxir
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(R)-(+)-Etomoxir |
Antioxidant
,
CPT
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Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. Etomoxir has an inhibitory eff... |
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T37299 |
L-Palmitoylcarnitine chloride
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Palmitoyl-L-carnitine is a naturally occurring long-chain acylcarnitine and the L-enantiomer of palmitoyl-DL-carnitine . In cells, palmitoyl-L-carnitine is transported into mitochondria via carnitine palmitoyl transferas... |
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T1415 |
Gemfibrozil
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CI-719,Jezil,Decrelip,Lopid |
P450
,
Adrenergic Receptor
,
PPAR
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Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi... |
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T68447 |
BM-42304
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BM-42304 is an inhibitor of fatty acid oxidation. |
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T68692 |
Palmoxirate sodium hydrate
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Palmoxirate sodium hydrate is a potent inhibitor of long-chain fatty acid oxidation. |
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T68370 |
Sdz 51641
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Sdz 51641 is an inhibitor of fatty acid oxidation which is highly selective for the liver. |
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T9768 |
Ninerafaxstat
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Others
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Ninerafaxstat hifts cellular metabolism from fatty acid oxidation to glucose oxidation.Ninerafaxstat decreases fatty acid oxidation and improve overall mitochondrial respiration.Ninerafaxstat inhibit the growth and proli... |
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T68196 |
Aminocarnitine
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Aminocarnitine is an inhibitor of fatty acid oxidation that acts as a hypoglycemic and antiketogenic compound. It alters lipidic metabolism by inhibiting carnitine acetyltransferase (CAT) and carnitine palmitoyltransfera... |
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T22444 |
Trimetazidine
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Others
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Trimetazidine, an anti-ischemic (anti-anginal) metabolic agent, could improve myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxid... |
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T36611 |
(±)13-HODE
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(±)13-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. It is the principle hydroxylated fatty acid in human psoriatic skin scales, with a mean concentrat... |
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T37157 |
8(S)-HEPE
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8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor. |
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T26935 |
C108297
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C-108297,C 108297 |
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C108297 is a glucocorticoid receptor modulator. C108297 prevents both diet-induced obesity and inflammation. C108297 decreased food and fructose intake and increased lipolysis in white adipose tissue (WAT) and free fatty... |
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T73829 |
Malonyl CoA
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Malonyl CoA serves as a substrate in fatty acid biosynthesis while inhibiting fatty acid oxidation. It also acts as a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 [1] [2]. |
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T37405 |
Octanoyl Coenzyme A (sodium salt)
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Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β... |
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T37407 |
Arachidonoyl-L-carnitine (chloride)
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C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride) |
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Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnit... |
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T36604 |
(±)5-HETE
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(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrop... |
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T36559 |
(±)9-HODE
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(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of ... |
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T35462 |
(±)11-HETE
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(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid . The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPL... |
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T38189 |
2-hydroxy Lignoceric Acid
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2-hydroxy Lignoceric acid is an α-hydroxy very long chain fatty acid that is normally present in the mammalian nervous system. In the brain, 2-hydroxy lignoceric acid is derived from lignoceric acid and further converted... |
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T36558 |
(±)9-HETE
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(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC.... |
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T35507 |
12-HETE
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(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers . It aggregates ne... |
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T37634 |
17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
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Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by asp... |
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T78569 |
CPT2
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Carnitine palmitoyltransferase 2 |
Apoptosis
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Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC). Overexpression of CPT2 activates phosphorylated p53, enhancing its expres... |
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T73088 |
Mavodelpar
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HPP593,REN001,REN001 ; HPP593 |
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Mavodelpar (REN001), a selective PPARδ agonist, effectively suppresses glomerular injury and renal fibrosis. It is utilized in the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation di... |
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T37867 |
9(S)-HpOTrE
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9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found... |
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T12342 |
P053
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Others
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P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor with an IC50 of 0.5 μM. P053 is an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle and regulator of whole-body ad... |
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T36601 |
(±)17-HDHA
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(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of D... |
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T36106 |
Coumermycin A1
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Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.
Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea... |
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T35504 |
(±)10-HDHA
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(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of... |
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T35698 |
Octanoic Acid-13C
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from g... |
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T36608 |
(±)8-HEPE
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(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the pres... |
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T35813 |
CAY10592
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|
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Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm... |
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T35881 |
Resolvin E2
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-... |
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T37971 |
12-oxo-13-HOME
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12-oxo-13-HOME is an oxylipin derived from linoleic acid .1It is formedviaa 13-HpODE intermediate that is produced by lipoxygenase-mediated metabolism of linoleic acid.2,3,112-oxo-13-HOME has been found in corn and sunfl... |
